Short-term, easy pleasure leads to long-term, deep suffering while short-term suffering leads to long-term pleasure.

For the examples of the former, think smoking a cigarette or taking a hit of cocaine.

For the latter, think being pregnant and giving birth that leads to the most intense pleasure in life which is having children. Or something simpler, such as working out or learning another language.

As Arestovich says, the greatest fear of the perennially scared and the perpetually harmed is living without fear. Being terrified is the only organizing principle they have.